Stylized blue silhouette of a head with a ladder rising from an orange floor to a light at the top of the form, an architectural metaphor for the path up out of treatment-resistant depression
For Treatment-Resistant Depression

When the Last Antidepressant Didn't Work.

Treatment-resistant depression is not a category we treat at the margin. It is the patient population this practice was built for.

01 · TMS

Transcranial Magnetic Stimulation.

50–60% respond · ~40% remission

Gentle magnetic pulses stimulate underactive brain regions involved in mood regulation. FDA-approved for major depressive disorder and OCD in patients ages fifteen and up. A typical course runs across weekday sessions over several weeks at the Medical District location.

02 · Spravato

Esketamine, Administered On Site.

70% improvement · ~50% remission

Spravato is a nasal-spray esketamine treatment for treatment-resistant depression, administered on site under medical supervision per the FDA REMS protocol. A typical course begins with twice-weekly sessions tapering across the first two months.

03 · GeneSight

Pharmacogenetic Testing.

A single cheek swab

GeneSight analyzes how a patient's genes affect medication metabolism, reducing trial-and-error in medication selection. Used at the practice both for new patients with no prior trials and for established patients whose current regimen is not working.

All three offered on site · Medical District for TMS and Spravato · Both locations for medication management and GeneSight

The Curve We Watch.

A typical PHQ-9 trajectory across a TMS course at Stillwater. The dashed line is the response threshold, where depression severity steps down out of moderate. Most patients cross it around week four.

24 18 12 6 0 PHQ-9 SCORE WEEK 0 1 2 3 4 5 WEEK 6 SEVERE MODERATELY SEVERE MODERATE RESPONSE THRESHOLD · PHQ-9 = 10 RESPONSE WEEK 4 Threshold crossed.
0% TMS Response Rate Patients with at least 50% reduction in depression severity over a typical course.
0% Spravato Remission Patients reaching depression-free status with esketamine plus an oral antidepressant.
0% GeneSight Impact Patients on a medication their genetics suggest may not be the right metabolic fit.
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